Increased vascular catecholamine sensitivity and alpha-adrenergic receptor affinity in female and estrogen-treated male rats.
نویسندگان
چکیده
Wilson S. Colucci, Michael A. Gimbrone, Jr., Margaret K. McLaughlin, William Halpern, and R. Wayne Alexander From the Cardiovascular Divison and the Vascular Pathophysiology Laboratory, Brigham and Women's Hospital, the Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts; and Departments of Obstetrics and Gynecology and of Physiology and Biophysics, University of Vermont Medical Center, Burlington, Vermont
منابع مشابه
Increased Vascular Catecholamine Sensitivity and a-Adrenergic Receptor Affinity in Female and Estrogen-Treated Male Rats
Wilson S. Colucci, Michael A. Gimbrone, Jr., Margaret K. McLaughlin, William Halpern, and R. Wayne Alexander From the Cardiovascular Divison and the Vascular Pathophysiology Laboratory, Brigham and Women's Hospital, the Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts; and Departments of Obstetrics and Gynecology and of Physiology and Biophysics, University o...
متن کاملRegulation of myocardial and vascular alpha-adrenergic receptor affinity. Effects of guanine nucleotides, cations, estrogen, and catecholamine depletion.
The threshold sensitivity of cardiovascular tissues to alpha-adrenergic stimulation is determined largely by the affinity of alpha-adrenergic receptors for agonists. To determine whether changes in alpha-adrenergic receptor affinity could contribute to the regulation of cardiac and vascular responsiveness, we used the alpha-adrenergic-selective radioligands, [3H]prazosin, [3H]-WB-4101, and [3H]...
متن کاملRegulation of the postsynaptic alpha-adrenergic receptor in rat mesenteric artery. Effects of chemical sympathectomy and epinephrine treatment.
Vascular smooth muscle sensitivity to catecholamine-induced contraction is increased after catecholamine depletion by chemical sympathectomy and decreased after exogenous catecholamine administration. To investigate the role of the vascular o-adrenergic receptor in these alterations, we used the a-1 selective radioligand, (H)-WB-4101, [phenoxy-3-H(JV)]-(2-(2,6-dimethoxyphenoxyethyl)aminomethyl-...
متن کاملCardiovascular baroreflex sensitivity attenuates by cisplatin-induced toxicity in rats
Introduction: Cisplatin (CP) therapy may disturb cardiovascular system control. The objective of this study was to find baroreflex sensitivity (BRS) in CP-induced nephrotoxicity in rats. Materials and Methods: Eighteen male and female Wistar rats were randomly assigned to two groups treated with CP (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical ...
متن کاملIncreased alpha-adrenergic receptor affinity in resistance vessels from hypertensive rats.
alpha-Adrenergic receptor-related properties, specifically, norepinephrine affinity, occupancy and reserve during contraction, were determined in segments of rat resistance arteries. These were obtained from the superior mesenteric bed of spontaneously hypertensive rats and Wistar-Kyoto strain controls. Receptor affinity for norepinephrine in the spontaneously hypertensive rats was significantl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation research
دوره 50 6 شماره
صفحات -
تاریخ انتشار 1982